Livedoid vasculitis
Livedoid vasculitis ke lefu le sa foleng la letlalo le bonoang haholo ho basali ba banyane ho isa ho ba lilemong tse mahareng. Tlhaloso e 'ngoe e sebelisetsoang ho hlalosa likarolo tsa eona ke "Maqeba a bohloko a purpuric a nang le mokhoa oa reticular oa lipheletsong tse ka tlaase" (PURPLE). E amahanngoa le maloetse a mangata, ho kenyelletsa le khatello ea kelello e sa foleng ea venous le varicosities.
☆ Liphethong tsa 2022 Stiftung Warentest tse tsoang Jeremane, khotsofalo ea bareki ka ModelDerm e ne e le tlase hanyane ho feta lipuisano tse lefelloang tsa telemedicine.
E ka tsamaea le bohloko.
References
Livedoid vasculopathy ke boemo bo sa tloaelehang ba letlalo bo khetholloang ke liso tse bohloko tse lulang li khutla maotong a tlase.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy ke boemo bo sa tloaelehang ba letlalo bo bakang liso tse iphetang maotong a ka tlase, tse sieang maqeba a masoeu a tsejoang e le atrophie blanche. Le hoja ho ntse ho e-s'o hlake hantle hore na sesosa ke sefe, ho lumeloa hore ho eketseha ha mali (hypercoagulability) ke eona ntho e ka sehloohong, ka lebaka la ho ruruha ho bapala karolo ea bobeli. Lintlha tse tlatsetsang ho hoameng li kenyelletsa tse latelang - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Li-biopsies, boemo bona bo bontša maqeba a mali ka har'a lijana, ho teteana ha marako a sekepe, le maqeba. Kalafo e kenyelletsa mekhoa e mengata e tsepamisitseng maikutlo ho thibela ho ruruha ha mali ka meriana e kang li-anti-platelet lithethefatsi, mali a fokolang mali, le phekolo ea fibrinolytic. Lithethefatsi tse fapaneng li ka sebelisoa bakeng sa boemo bona ba letlalo - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy ke boemo bo sa tloaelehang moo maqeba a hlahang maotong ka bobeli. Ho nahanoa hore ho thehoa ha mali ka har'a methapo e menyenyane ea mali ho bakoa ke ho eketseha ha lesela le ho fokotseha ha lesela, hammoho le tšenyo ea lesela la sekepe. E atile haholo ho basali, haholo-holo pakeng tsa lilemo tse 15 le 50. Ho khaotsa ho tsuba, ho itlhokomela maqeba, le ho sebelisa meriana e kang e fokotsang mali le litlhare tse thibelang mali ho sebetsa.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
